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Some Studies of Magnesium treatment for Depression

Posted by Mtom on September 7, 2021, at 13:19:57

Clinical Studies of Magnesium Supplementation in Depression:

Published 2006 in Medical Hypotheses: Rapid recovery from major depression using magnesium treatment. Eby & Eby.
This was a series of several cases studies and concluded, in part, that this report supports the overall hypothesis that magnesium is therapeutic for depression and related mental disorder. Read full paper for details on forms of magnesium (which according to the authors, is important).

Published in PLOS ONE 2017: Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. Emily K. Tarleton et al.
This study used four 500 mg tablets of magnesium chloride daily for a total of 248 mg of elemental magnesium per day. Concluded: this efficacy trial showed magnesium supplements may be a fast, safe, and easily accessible alternative, or adjunct, to starting or increasing the dose of antidepressant medications.

There are several other studies examining the relationship of magnesium and depression but most of those Ive read tried to find associations between dietary magnesium and depression (i.e. retrospective studies which many consider unreliable), others measured plasma levels of magnesium (which others argue is not a reliable marker of magnesium status). Many were inconclusive because of this.

One other small placebo controlled Clinical study With 37 participants published in 2018 combined fluoxetine with only 120 mg per day of Magnesium aspartate (a much lower dosage of Magnesium than used in the 2 studies above). More participants on fluoxetine plus Magnesium showed decreases in their HDRS scores than those on fluoxetine plus placebo, although the authors found these differences not statistically significant (likely due to the low number of participants in each group) In addition, the first study cited above found that Magnesium aspartate (and glutamate) worsened one patients depression, while other forms of Magnesium improved it significantly. Details in that study above.

Magnesium is important in many cellular functions and for optimal health. Some believe our soils have been depleted of Magnesium by years of intensive farming, resulting in lower amounts in our diets over the years versus historically. I have been using Magnesium Bis-Glycinate (or glycinate), easy on the gut and a quite low dose which I will increase, and recently have added some Magnesium L-Threonate, an interesting form you can google (although much pricier).




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