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Re: Which Antioxidants do not have CYP interactions?

Posted by Mtom on July 12, 2020, at 13:31:27

In reply to Which Antioxidants do not have CYP interactions?, posted by Lamdage22 on July 3, 2020, at 3:23:54

I've had the same question and have done some research. Here's one paper on Curcumin interacting with meds including antidepressants and others:
Pharmacokinetic interactions of curcuminoids with conventional drugs: A review
RoodabehBahramsoltaniabRojaRahimiabMohammad HoseinFarzaeicd

Published in Journal of Ethnopharmacology Volume 209, 14 September 2017.

I've read similar cautions about curcumin in other articles.

Making it complicated, there are a lot of foods with potential for interactions. Grapefruit has been well known for many years, but I've seen articles suggesting a number of other foods including fruits and vegetables may interact (mostly in vivo and some animal studies). Also that CBD Oil could interact as it influences some of the same liver P450 CYP enzymes that meds interact with (I think mostly in vitro studies, and I don't remember ever seeing a dosage at which this might happen).

I've thought about taking some Vitamin E with my Fish Oil, but most single supplements tend to be mega-doses compared to the RDI. And this could be problematic with Vitamin E. Also Vitamin E can also thin blood (as can, hypothetically, large doses of omega-3's).

I have squeezed the contents of a few high dose Vitamin E gel caps into my bottled Omega-3 supplement, goal to help protect again oxidation during storage (although in dark bottle stored in fridge - but I open it daily....).

Here's an article that states Fish Oil can lower levels of Vitamin E - but it refers to a an old 1991 study:

I'll try doing more research, and please post if you find something relevant. Thanks!




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