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Re: Where would you be without my meds - Scott deniseuk190466

Posted by SLS on January 29, 2024, at 21:43:20

In reply to Re: Where would you be without my meds - Scott, posted by deniseuk190466 on January 29, 2024, at 6:03:24

> Hi Scott,
>
> I was doing well but then I asked to be switched from Seroxat to Prozac and then the extreme anxiety started again. Luckily the Zyprexa does help with that. Back on the Seroxat now and feeling better.

Man, you just made my day.

> Are you saying that people with the most severe depression are more likely to have a placebo response or less likely?

In any one modern clinical trial, people who are severely depressed are the most likely to achieve remisssion.


> I don't know what is wrong with me any more but I know for a fact that I've never had a placebo response to anything related to my mood.

You are a perfect example of my criticism of modern clinical trials for antidepressants. Today's placebo response rate is much higher than that seen in the 1960s, 1970s, and early 1980s. The reason? Today's clinical trials are all paid for by drug companies rather than being projects funded and conducted by university research departments. They were very strict as to who they chose as subjects. Today, drug companies pay clinical trial centers, which are in business. Businesses act to make as much money as possible. They get paid for each person they recruit. They are NOT strict with who they allow in to the study. Severe depression turns out to be the smallest study group. The rest are presentations of dysthymia (minor depression), psychologically depressive thinking, childhood adversity leading to complex post-traumatic stress disorder (CPTSD).

People who do *not* have MDD are accepted into a clinical trial because there is more money to be made by taking in people who don't have MDD, but complain of depression. These subjects are much more apt to report feeling better when they are given hope with the new support system they have received at the clinical center. People who are psychologically depressed with no biological contribution are certainly more apt to respond to placebo. You can research the placebo response by researching the work performed by Frederick Quitkin, MHRIP.

Clinical trial screener: "Are you depressed?".

Prospective subject: "Yes".

Clinical trial screener. "Okay, we can sign you up right now."

> You could say "well how would you know? if your response is placebo or not?"

You wouldn't until the trial is over and the investigators perform a "blind-breaking" with you and tell you what you were given. If you were given sugar pills, only then will you be told.

Gotta go...

Get well and stay well...


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1122302
URL: http://www.dr-bob.org/babble/20230117/msgs/1122315.html