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Re: Where would you be without my meds deniseuk190466

Posted by SLS on January 22, 2024, at 22:27:49

In reply to Re: Where would you be without my meds, posted by deniseuk190466 on January 19, 2024, at 10:29:39

> Hi Scott,
>
> Sorry but I am really struggling to concentrate lately. My mind just keeps wondering all the time to death and suicide and why am I like I am and why can't I just be normal etc and just general anxiety and inability to sit still and focus!!!


Damn it. I'm sorry, Denise. I really am. I misunderstood your words, and thought that you were doing well. You are truly heroic in your fight to stay alive.

> Thanks for all of the information, it's quite heavy reading.
> I am interested in your paragraph about the placebo response. Why do you think that it is so much higher since the 1990s?


Too many subjects chosen for clinical trials simply don't have the disease being studied. Without going into too much detail, the proof of this is that those subjects who have the severest of depressions respond more often than the rest of the population in a study. Severe depression is much more likely to be a presentation of Major Depressive Disorder than subjects admitted to the study with milder presentations. These often have other causes, including purely psychological ones. For example, true dysthymia, sometimes called minor depression, responds poorly to antidepressants. Yet, they are depressed enough to meet the study inclusion criteria.

In my estimation, MONEY is the explanation for poor response rates and exaggerated placebo rates. Business owners of clinical trial centers don't give a damn how accurate their screening process is. Pharmaceutical companies pay them according to how many subjects they recruit. The rest is easy to figure out.

Disgusting.


Again -


1. 1960s / 1970s / 1980s:
- Response Rate = 65-69%
- Placebo Rate = 15-25%

2. Today
- Response Rate = 46%
- Placebo Rate = 35-40%


This is a dangerous farce. Good drugs fail to get approved.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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