Psycho-Babble Medication | about biological treatments | Framed
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Re: Nortriptyline addition (25mg) seems to help - Oops

Posted by PeterMartin on November 3, 2023, at 12:47:19

In reply to Nortriptyline addition (25mg) seems to help - Oops, posted by SLS on October 30, 2023, at 17:26:54

> Sorry.
> A lack of proofreading.
> I found nortriptyline to be a better anti-anhedonic than is desipramine. Your experience might end up being just the opposite, of course. Desipramine feels harsh to me and left me feeling "wired" and accelerated my heart-rate far more than nortriptyline.
> I don't know if this is helpful, but for me, desipramine feels more like methylphidate, while nortriptyline feels more like amphetamine. However, if you fail to respond to one, you might yet respond to the other.
> - Good Luck

Appreciate your insight! Yea we tried a small dose of Desipramine about a year ago and I couldn't tolerate it. My heart-rate got too quick, and I got very hot/started sweating at room temperature. I only took it for a couple weeks due to that.

So far Nort has been pretty easy w/ the side effects now being 6ish weeks into my small dose adjunct trial. Constipation is my main issue mainly because other meds I take cause it also...

Thanks a lot also for clarifying on "anti-anhedonic" (vs. the typo) in your earlier post. I was about to comment and ask on that ha. One of the main features of my depression/BP when I have bad days/weeks at this point is inability to pick up things I enjoy (and still WANT to enjoy). I find it's a common symptom in this day and age per groups on Reddit/Discord......

I'm hoping I can stay low on NPT and have it just reignite some of the waned Marplan/Lamictal benefits - I've been on those for 13+yrs now.




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