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Re: Actions of Nefazadone as SSRI add-on porkpiehat

Posted by SLS on July 31, 2023, at 23:14:44

In reply to Actions of Nefazadone as SSRI add-on, posted by porkpiehat on July 26, 2023, at 13:48:46

mCPP often produces anxiety, headaches, reduced appetite, and sweating. i think it is a metabolite of mCPP that has properties similar to ecstasy. If fluoxetine inhibits the metabolism of mCPP, I would look at its increased accumulation as a possible culprit for the effects you describe. I have never heard of mCPP itself to have positive effect on depression. If anything, it might actually worsen depression.

I don't know enough to be certain.

My guess is that your initial robust response to nefazodone was real and due to the actions of nefazodone (parent compound), and not its mCPP metabolite (daughter compound). Try looking for a drug with the same properties as the nefazodone molecule without a mCPP metabolite.

Just guessing.

https://en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine


meta-Chlorophenylpiperazine (mCPP) is a psychoactive drug of the phenylpiperazine class. It was initially developed in the late-1970s and used in scientific research before being sold as a designer drug in the mid-2000s.[3][4] It has been detected in pills touted as legal alternatives to illicit stimulants in New Zealand and pills sold as "ecstasy" in Europe and the United States.[5][6]

Despite its advertisement as a recreational substance, mCPP is actually generally considered to be an unpleasant experience and is not desired by drug users.[5] It lacks any reinforcing effects, but has "psychostimulant, anxiety-provoking, and hallucinogenic effects."[7][8][9][10] It is also known to produce dysphoric, depressive, and anxiogenic effects in rodents and humans,[11][12] and can induce panic attacks in individuals susceptible to them.[13][14][15][16] It also worsens obsessivecompulsive symptoms in people with the disorder.[17][18][19]

mCPP is known to induce headaches in humans and has been used for testing potential antimigraine medications.[20][21][22] It has potent anorectic effects and has encouraged the development of selective 5-HT2C receptor agonists for the treatment of obesity as well.[23][24][25][26]

- Scott



Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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