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Re: Many drugs likely cause changes to dopamine system

Posted by SLS on July 6, 2023, at 11:52:32

In reply to Many drugs likely cause changes to dopamine system, posted by Jay2112 on July 5, 2023, at 19:08:21

In 1983, I began researching affective disorders at the Rutgers medical school library. After poking around there for a few weeks, I proposed to the clinical research division of psychiatry at Columbia Presbyterian (now Coumbia-Cornell) a theory that I had devised suggesting a role for dopamine in the pathogenesis of depression - especially in bipolar disorder. After failing 7 or 8 antidepressant trials, I asked them for Wellbutrin, which was not yet available. Compassionate use? Harrison and Quitkin said that they would consider it if I were to go for 6 months of psychotherapy. So, I asked about bromocriptine. Harrison said to me, "That's fine if you want to throw up all day", and laughed at me. I left and found someone who was working with Wellbutrin on an open-label basis.


In 1983, I could find only one author who proposed a role for dopamine in depression. I felt vindicated. Considering that a role for dopamine had been proposed in the medical literature by 1977, I really should not have been dismissed so quickly. I had my eye on a drug called nomifensine. It was described as a potent dopamine reuptake inhibitors in addition to being a norepinephrine reuptake inhibitor. Amineptine was another DA reuptake inhibitor available in France, but was withdrawn from the market when the Olympic committee banned it as a performance-enhancing drug. Eventually, nomifensine was approved by the FDA in 1984 and named Merital. I had to beg Baron Shopsin to prescribe it for me. He said that the drug was a piece of sh*t, but acquiesced. People who were treatment resistant to all other antidepressants responded robustly to nomifensine. Unfortunately, reports of hemolytic anemia were emerging in association with nomifensine. In 1992, the FDA withdrew its approval, and nomifensine was withdrawn from the market worldwide. That was the decision of Hoechst-Roussell.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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