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Re: To SLS

Posted by undopaminergic on April 12, 2023, at 7:49:13

In reply to Re: To SLS, posted by SLS on April 11, 2023, at 21:17:41

Hi SLS and Roslynn.

> Undopaminergic is really sharp - sharper than me.

Thank you for the praise!

> > But effexor plus serzone is one of Stahl's heroic combos, right?
> It's been a long time, but I think Stahl recommended combining Effexor with Remeron (mirtazapine). I first saw it in the medical literature in 2000, but the literature was a few years older. There was a lot enthusiasm at first. However, it never really took root. I'm not exactly sure why, but perhaps this article will explain things:

I'm not familiar with Stahl's heroic combos, but I do know that the name heroin was a reference to heroism.

> I might look for some literature about combining a tricyclic with mirtazapine. Together, they should increase norepinephrine neurotransmission through two different mechanisms. I don't recall seeing anyone take it.
> I'd be interested to know what Undopaminergic thinks of this.

If you benefit from more noradrenaline (-epinephrine), or want to test whether you do, it is indeed an interesting combination. It's probably not good for your cardiovascular system though. Also, the antihistamine effects of mirtazapine may dampen the "stimulant-like" noradrenergic effects. Yohimbine would be a more selective alternative to mirtazapine. On the other hand, the serotonin 5-HT2A antagonism of mirtazapine may be a positive aspect.





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