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Re: Dayvigo SLS

Posted by undopaminergic on April 8, 2023, at 8:22:19

In reply to Re: Dayvigo, posted by SLS on April 4, 2023, at 19:58:20

> Hi, UD.


> > > Another drug that might be worth looking at isto treat insomnia is trimipramine (Surmontil). In contrast to other tricyclic antidepressants, trimipramine:
> > >
> > > 1. Increases sleep efficiency.
> > >
> > > 2. Does not reduce REM sleep, and tends to enhance it.
> > >
> > > 3. Does not inhibit the reuptake of norepinephrine-NE (noradrenalin-NA), serotonin (5-HT) or dopamine (DA).
> > >
> > > 4. Has mild antipsychotic effects.
> > "Substantial" according to a German study comparing it to perazine.
> >
> > > 5. Produces very little rebound insomnia upon discontinuation.
> > >
> > > 6. Is tolerated better than doxepin.
> > >
> >
> > It also reduces cortisol secretion.
> I envy your memory. It's almost as good as Linkadge's.

Despite that, my memory is not what it was before I got burnt out and depressed.

> To be accurate, some studies detected a slight bit of reuptake inhibition. Who knows?

Linkadge cited a study suggesting that, in vivo, venlafaxine is a much stronger noradrenaline (norepinephrine) reuptake inhibitor than in vitro data would suggest. So, I suppose that theoretically, something similar might be true of trimipramine.

> Trimipramine inhibits cortisol secretion? That's excellent. The "stress" hormone? In short bursts, cortisol reduces inflammation. However, chronic hypercortisolism produces the opposite effect. Brain inflammation is the result.

Interesting. I wasn't aware of that. It's worth mentioning however, that taking trimipramine at night might serve to normalise a disturbed cortisol concentration circadian curve. It should be lower during night and increase in the morning.

I forgot to mention one fact about trimipramine that I consider important. It is a centrally active histamine H2-receptor antagonist. This is a rare property, shared by clozapine. As far as I'm aware, H2-antagonists used for heartburn and other gastrointestinal conditions cross the blood brain barrier only partially, if at all, and before they were introduced trimipramine was sometimes used in their place.





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