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Re: Dayvigo

Posted by SLS on April 4, 2023, at 19:58:20

In reply to Re: Dayvigo SLS, posted by undopaminergic on April 2, 2023, at 8:17:05

Hi, UD.

> > Another drug that might be worth looking at isto treat insomnia is trimipramine (Surmontil). In contrast to other tricyclic antidepressants, trimipramine:
> >
> > 1. Increases sleep efficiency.
> >
> > 2. Does not reduce REM sleep, and tends to enhance it.
> >
> > 3. Does not inhibit the reuptake of norepinephrine-NE (noradrenalin-NA), serotonin (5-HT) or dopamine (DA).
> >
> > 4. Has mild antipsychotic effects.

> "Substantial" according to a German study comparing it to perazine.
> > 5. Produces very little rebound insomnia upon discontinuation.
> >
> > 6. Is tolerated better than doxepin.
> >
> It also reduces cortisol secretion.

I envy your memory. It's almost as good as Linkadge's.

To be accurate, some studies detected a slight bit of reuptake inhibition. Who knows?

Trimipramine inhibits cortisol secretion? That's excellent. The "stress" hormone? In short bursts, cortisol reduces inflammation. However, chronic hypercortisolism produces the opposite effect. Brain inflammation is the result.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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