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Re: Dayvigo SLS

Posted by undopaminergic on April 2, 2023, at 8:17:05

In reply to Re: Dayvigo undopaminergic, posted by SLS on April 1, 2023, at 12:25:54

> Hi.
> > > I have read of Dayvigo. It blocks hypocretin (which helps keep you awake) in the brain. I haven't tried it, but have heard of the sleepwalking. Personally, I prefer benzos for sleep.
> > >
> >
> > Benzos are effective for promoting sleep, but in my experience, it is an absolutely worthless sleep. If antihistamines work for you, I would prefer them, although they take longer than benzos to induce sleep.
> >
> > -undopaminergic
> What about Seroquel (quetiapine)? People really do well with it at low dosages - 25-50 mg/day. Does it affect sleep architecture?

I don't know, but it's an antihistamine (H1 receptor) and a serotonin 5-HT2A antagonist. The latter does not appear to contribute to sedation, but may improve sleep quality. Cyproheptadine (Periactin) is another one that affects the same receptors.

> Benzodiazepines are supposed to affect negatively sleep architecture. I found tempazepam (Restoril)and lorazepam (Ativan) to be the best of the bunch for insomnia. I prefere Ambien (zolpidem). It impacts sleep architecture minimally or not at all - especially REM sleep. Ambien puts me to sleep quickly and with no hangover the next morning.

It used to work the same for me many years ago, but later it had little or no effect (the same is true for temazepam).

> It does have a short half-life. However, I don't experience rebound awakenings like I did with triazolam (Halcion), another drug with a short half-life. For this reason, I took both lorazepam and triazolam. Triazolam put me to sleep and lorazepam kept me asleep. I needed this to remedy total insomnia while I was taking a combination of Parnate + desipramine.
> Another drug that might be worth looking at isto treat insomnia is trimipramine (Surmontil). In contrast to other tricyclic antidepressants, trimipramine:
> 1. Increases sleep efficiency.
> 2. Does not reduce REM sleep, and tends to enhance it.
> 3. Does not inhibit the reuptake of norepinephrine-NE (noradrenalin-NA), serotonin (5-HT) or dopamine (DA).
> 4. Has mild antipsychotic effects.

"Substantial" according to a German study comparing it to perazine.

> 5. Produces very little rebound insomnia upon discontinuation.
> 6. Is tolerated better than doxepin.

It also reduces cortisol secretion.





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