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Re: An update Jay2112

Posted by undopaminergic on February 17, 2023, at 11:16:50

In reply to Re: An update tensor, posted by Jay2112 on February 16, 2023, at 20:19:20

> That is excellent you reacted well to Chlorprothixene!! I take a low dose of a FGA too, one called Nozinan (Methoprazine).

The first time I heard the name Nozinan, I thought it was something for the nose, maybe a decongestant.

Soon enough I learned it was an antipsychotic known as levomepromazine. Today is the first time I've heard the term methoprazine. Wikipedia doesn't mention that name at all, but does note that it is also known as methotrimeprazine.

I was offered it for sleep but never used it. When I mentioned concerns about residual sedation in the morning, they offered me chlorprothixene (Truxal). I never used that either, as it wasn't needed, but actually I'd like to try it for comparison with flupenthixol (Fluanxol), as they are structurally related, both belonging to the thioxanthene class of antipsychotics.

Flupenthixol has some antidepressive properties, but did not appear to work for me. I may try it again as part of combinations, as it may have a unique mechanism of action (it hasn't been elucidated to my knowledge) to contribute. It did not have any noticeable sedative or appetite-stimulant actions in my experience, but at higher doses, it gave me worse anorgasmia than SSRIs, and at one point (at more moderate doses) I was experiencing what seemed to be restless legs syndrome.





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