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Re:Neuroleptics brain specific antihistaminergic? SLS

Posted by undopaminergic on February 7, 2023, at 11:15:54

In reply to Re:Neuroleptics brain specific antihistaminergic?, posted by SLS on February 6, 2023, at 19:11:09

> I'm not sure how many pathways / neurotransmitters are involved with sleep. It's more than one, though.

Dopamine too. I find it particularly interesting that dopamine neurons involved in wakefulness have been found in a region called the ventral periaqueductal gray (vPAG):
"Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter"

> Hypocretin (orexin) is important in maintaining wakefulness. Hypocretin was first labeled as being a neuropeptide. Later, it was found in synaptic vesicles, so it is now often considered to be a neurotransmitter. Another substance that reduces wakefulness and promotes sleep is adenosine. Unlike hypocretin, it is not found in presynaptic vesicles, and is therefore considered a neuropeptide. Adenosine is liberated from the cell membrane along the neuron and into the fluid. There are several types of adenosine receptor. The major role of adenosine is to inhibit wakefulness and promote sleep. Caffeine produces its stimulatory behavioral effects by blocking adenosine receptors, and thus prevents adenosine from performing its role to oppose wakefulness.

I think maybe what you mean by "neuropeptide" is "neurohormone" or "neuromodulator". A neuropeptide is a substance that (1) has a peptide structure, and that (2) is involved with the nervous system. Orexin does have a peptide structure, but adenosine does not.





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