Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re:Neuroleptics brain specific antihistaminergic? SLS

Posted by undopaminergic on February 7, 2023, at 11:15:54

In reply to Re:Neuroleptics brain specific antihistaminergic?, posted by SLS on February 6, 2023, at 19:11:09

>
> I'm not sure how many pathways / neurotransmitters are involved with sleep. It's more than one, though.
>

Dopamine too. I find it particularly interesting that dopamine neurons involved in wakefulness have been found in a region called the ventral periaqueductal gray (vPAG):
https://pubmed.ncbi.nlm.nih.gov/16399687/
"Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter"

> Hypocretin (orexin) is important in maintaining wakefulness. Hypocretin was first labeled as being a neuropeptide. Later, it was found in synaptic vesicles, so it is now often considered to be a neurotransmitter. Another substance that reduces wakefulness and promotes sleep is adenosine. Unlike hypocretin, it is not found in presynaptic vesicles, and is therefore considered a neuropeptide. Adenosine is liberated from the cell membrane along the neuron and into the fluid. There are several types of adenosine receptor. The major role of adenosine is to inhibit wakefulness and promote sleep. Caffeine produces its stimulatory behavioral effects by blocking adenosine receptors, and thus prevents adenosine from performing its role to oppose wakefulness.
>

I think maybe what you mean by "neuropeptide" is "neurohormone" or "neuromodulator". A neuropeptide is a substance that (1) has a peptide structure, and that (2) is involved with the nervous system. Orexin does have a peptide structure, but adenosine does not.

-undopaminergic


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:undopaminergic thread:1121718
URL: http://www.dr-bob.org/babble/20230117/msgs/1121754.html