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Re: Are Neuroleptics brain specific anticholinergics? SLS

Posted by undopaminergic on February 5, 2023, at 16:15:47

In reply to Re: Are Neuroleptics brain specific anticholinergics? Lamdage22, posted by SLS on February 5, 2023, at 11:17:10

> Hi.
> I agree with UD.
> I wonder, though, if the BBB barrier prevents some substances from exiting the brain that it had previously allowed to enter it. If this occurs, then I imagine the concentration of a drug in the brain becomes higher than that in the rest of the body. Could be.

I can't clarify your question about the BBB possibly retaining substances. However, another mechanism for accumulation of a substance in the brain is if the substance is lipophilic, in which case the concentrations will be higher in the brain (and other fatty tissues) than the bloodstream.





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