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Re: clomipramine insomnia - does it ever go away?

Posted by SLS on January 29, 2023, at 7:17:48

In reply to Re: clomipramine insomnia - does it ever go away? SLS, posted by undopaminergic on January 29, 2023, at 2:36:37

Hi.

> > Simplistic scenario: You reacted to normally sedating drugs by becoming activated. Perhaps the converse is also true. Perhaps this "paradoxical" reaction indicates that taking amphetamine, which normally produces activation, produces sedation in you.

> I saw someone claim that sleep on Dexedrine is of superior quality.

I don't remember R-amphetamine keeping me awake. 20 mg/day I think?

> I got extremely calm when I took my first dose of phenylethylamine (PEA) under selegiline treatment.
>
> It is often claimed that people with ADHD have a paradoxical calming reaction to stimulants. That was true of PEA for me, but not methylphenidate or other dopamine reuptake inhibitors.

You might be too young, but do you remember a drug called nomifensine (Merital)? It was developed and sold by Hoechst-Roussel. It was probably the strongest DA reuptake inhibitor that made it to the US market as an antidepressant. I think it was stronger than amineptine (sold in France and later withdrawn). Some people achieved remission with nomifensine who responded to nothing else. I did. But, as usual, the improvement (nearly full remission) that I experienced disappeared in 3-4 days. Unfortunately, for those who relied upon nomifensine to return to a normal life, nomifensine was withdrawn from the market worldwide. These people were forced to drop out of life again. In the United states, it was available for only 3 years (1982-1985). There were a few reports of nomifensine being associated with hemolytic anemia. Some people had also developed antibodies to the drug and caused immunohemolytic anemia. Otherwise, I think it would have made a good treatment for TRD.

Amineptine, a dopamine reuptake inhibitor, represents one of my pet peeves regarding the availability of effective drugs that are safe when used properly. With amineptine, its withdrawal had nothing to do with efficacy or safety. I get angry whenever I think about it. The International Olympic Committee (IOC) banned amineptine as a performance-enhancing stimulant. That's it. That was enough for France to mandate its removal from the market.

Fentanyl (opioid): I am outraged about this one. I'm sure fentanyl (Duragesic) is soon to be withdrawn by the FDA as a response to public outcry. I'm very sorry that it kills people whose stash of heroin contains fentanyl, which is a much cheaper substance and easily acquired from the overseas black market. Fentanyl is an *essential* addition to the pharmacopeia. It is the most potent analgesic approved for marketing. It is the only drug capable of easing the excruciating pain of late-stage cancer. Ask a wife whose husband has terminal cancer if fentanyl should be made illegal.

Amineptine? Banned by the IOC as a performance enhancer? That it? What about amphetamine and anabolic steroids? Why didn't France make all of those drugs illegal, too?

If the FDA were to withdraw every drug that is abused for purposes other than medical, should the FDA make all of them illegal? Gee. What about acetaminophen (Tylenol)? Taking too much will kill. It causes fulminate liver failure in overdose. Should this substance be made illegal? I am outraged.

Fentanyl isn't the problem. Criminals are.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1121637
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