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Re: clomipramine insomnia - does it ever go away? SLS

Posted by undopaminergic on January 29, 2023, at 4:21:26

In reply to Re: clomipramine insomnia - does it ever go away? TriedEveryMedication, posted by SLS on January 28, 2023, at 11:28:14

> 2. If insomnia is the problem you are addressing, there are several medications that would probably give favorable results.
> zolpidem (Ambien) - Z-drug
> lorazepam (Ativan) - benzodiazepine
> temazepam (Restoril) - benzodiazepine
> clonazepam (Klonopin) - benzodiazepine
> quetiapine (Seroquel) - antipsychotic
> mirtazepine (Remeron) - antidepressant
> doxepin (Sinequan) - antidepressant (TCA) - Extremely antihistaminergic
> amitriptyline (Elavil) - antidepressant (TCA)
> trimipramine (Surmontil) - antidepressant (TCA)
> prazosin (Minipress) - Specific for PTSD nightmares.

What about cyproheptadine (Periactin)? It's an antihistamine but also blocks serotonin 5-HT2A, which may improve sleep quality.

> I prefer Z-drugs. If you ever need to discontinue Ambien, you can do so abruptly without having typical benzodiazepine withdrawal reactions. Insomnia can be a withdrawal reaction. For me, I had only partial insomnia as a withdrawal reaction to Ambien discontinuation. This might not be true of everyone. Zolpidem and triazolam (Halcion) are good for initial-insomnia while temazepam is good for sleep-maintenance. Many people like low-dosage quetiapine for both types of insomnia.

Midazolam (Dormicum) is another short-acting benzodiazepine suitable for sleep initiation, but it seems to be available (as Versed) only for injection in the US.

> About melatonin:
> 1. Melatonin can make depression somewhat worse.

Yet there is an antidepressant (agomelatine -- Valdoxan) that is a melatonin agonist.

> 2. The optimum timing of melantonin dosing varies between individuals. Most people find that 1 hour before bedtime works well. Yet, there are people who sleep much better when melatonin is given in the afternoon.

Dose is also important. There are people who insist that 300 mcg (micrograms) is better than higher doses.

> 3. Herbal teas. Valerian is mentioned often. Chamomile, lemon grass, and eleuthero are others with reputations as being sleep-aids.

Eleutherococcus is also called Siberian Ginseng.

I got angry from Valerian. It was very unusual in how it started and in its qualities. But it has only happened once.





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