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Re: Lithium biochemistry (low level mechanisms) SLS

Posted by undopaminergic on January 26, 2023, at 9:09:50

In reply to Re: Lithium biochemistry (low level mechanisms) undopaminergic, posted by SLS on January 26, 2023, at 8:58:54

> Hi, UD.


> Are there any data indicating what low vs high glutamate levels indicate with respect to mood?

Glutamate where? Hippocampus? Nucleus accumbens? Glutamate is the brain's predominant excitatory neurotransmitter, with many receptor subtypes. Global elevations or reductions will probably improve some functions and worsen others. But blocking NMDA-subtype receptors seems to ameliorate depression, at least judging from the effects of ketamine.





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