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Re: Lithium biochemistry (low level mechanisms) SLS

Posted by undopaminergic on January 25, 2023, at 12:24:00

In reply to Re: Lithium biochemistry (low level mechanisms) undopaminergic, posted by SLS on January 25, 2023, at 11:30:23

> > >
> > > According to a paper I found, there is a bimodal dosage distribution between low-dosage versus high-dosage lithium. Low dosages of lithium increased the release of glutamate in the hippocampus, while high dosages decreased it.
> > >
> >
> > Sounds a lot like the article I posted about at:
> >
> >
> > According to that, the reverse is true about hippocampal glutamate levels. In other words, lower lithium doses are associated with a reduction, and higher doses with an increase.
> >
> > -undopaminergic
> >
> This certainly needs more investigation. Obviously, it is important to know the relationship between glutamate levels and mood.
> - Scott

The article did not find a correlation between the glutamate levels and depressive status. I think some people benefit from a reduction and others from an increase. Or, (rarely?) the current level may be ideal.





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