Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Lamictal (lamotragine) dose 1 or 2 x a day? Jay2112

Posted by SLS on January 21, 2023, at 8:50:36

In reply to Lamictal (lamotragine) dose 1 or 2 x a day?, posted by Jay2112 on January 7, 2023, at 21:38:32

> I am restarting lamotragine. Just wondering:
> a) do I have to taper up again?

Yes. I would.

Lamotrigine is capable of producing Stevens-Johnson Syndrome (SJS), which can be fatal. As many as 10% of people starting lamotrigine will develop a rash, but only 0.04% will be due to SJS. SJS can show up with a latency of eight weeks after taking the first dose.

If lamotrigine therapy is to be restarted, even after a brief period of abstention, some guidelines mandate that you restart it as if it were your time taking it. One can restart lamotrigine, even if the first exposure precipitated a rash. In this case, it is recommended to wait eight weeks before restarting it. Not all rashes are Stevens-Johnson Syndrome. However, it can show up with a latency of eight weeks from the first dose. The dosage recommendations for treating bipolar depression is 100-400 mg/day. In my estimation, 200 mg/day is the sweet-spot that most people with bipolar depression. The recommended maximum dosage to treat seizure disorders is 500 mg/day. However, some people need as much as 700 mg/day. I need 300 mg/day. I have no side effects at this dosage. My memory and cognition seem to be unaffected now, but they did appear at the very beginning of treatment as a startup side effect.

> b) dose once or twice a day?

I would recommend twice-a-day dosing, although once-a-day is an option offered by the drug company. For bipolar depression, I think most clinicians will use a twice-a-day regimen. For me, at 300 mg/day, once a day dosing leaves me deteriorating into depression before each dose. Teva makes an extended release "Lamotrigine XR". I know nothing about its clinical dosing frequency.

> Also curious, it seemed to work well with methadone, helping with my rapid-metabolism problem. I zip through, metabolically, drugs very quick, methadone alone within anywhere from 2 to about 14 hours. (Through our estimates. He had me sit in his office after a dose, at about the 2 week mark, and my subjective estimate of effect was about 4 hours. I know...I know...much more is dependent.)

> Valproate inhibits the metabolism of lamotrigine quite a bit. I don't know at what dosage you would need to take it in order to match your metabolism. Is there any positive therapeutic effect of methadone that makes it an ideal adjunct?

> The literature doesn't mention a lot about lamotrigine use in concurrent disorders.

Which ones?

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1121507