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Re: Choose any 4 drugs to combine for remission.

Posted by SLS on January 18, 2023, at 23:46:03

In reply to Re: Choose any 4 drugs to combine for remission. SLS, posted by undopaminergic on January 16, 2023, at 10:16:23

I forgot to mention that Dr. Shopsin asked me to help him write a paper. He said I did better research than students at NYU who had a 170 I.Q. Unfortunately, he abruptly moved from Manhattan to Indianapolis, so I didn't have the opportunity to see my name on PubMed. Dr. Apter of Princeton University also asked me to write a paper. It was to be about buspirone. I had to tell him that I was far too cognitively impaired to be able to do it.

Jokingly, I say that Dr. Apter owes me some percentage of the millions of dollars he made because of something I said to him in 1994 while in the midst of a manic reaction to Nardil. I know it sounds funny and absurd, but I felt that he and I had figured out depression. I told him that he could take full credit for our discovery and the paper we would to write. Immediately after saying that, I told him that Alzheimer's Dementia was the disease that most urgently needed to be studied to find ways to treating it. This was in 1994.

I had originally stumbled upon literature describing Alzheimer's Dementia in 1983 or 1984. It was described as a rare, strange, and hideous disease. So, I spent some time every now and then to check out what was happening with Alzheimer's. Over the years, I followed the development of acetylcholine cholinesterase inhibitors as a treatment for Alzheimers. These drugs do for acetylcholine what MAOIs do for monoamine and indolemine neurotransmitters (NE, DA, 5-HT). Today, we
have three cholinesterase inhibitors approved for treating Alzheirmer's: donepezil, galantamine, and rivastigmine. There was initially a great deal of excitement about these drugs when they were first approved. Today, most neurologist consider them worthless, even when combined with memantine. I tried donepezil (Aricept). For me, it was inert.


So, it turns out that more than 10 years after this conversation, I discovered that he had discontinued his private practice opened up a center for running clinical trials for Alzheimer's, including investigational drugs. Drug companies descended on him and paid Dr. Apter to run their clinical trials. I still correspond with him every so often. I never brought up the conversation we had in 1994.

I could use the money.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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