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Finally trying vortioxetine -- initial impressions

Posted by undopaminergic on December 9, 2022, at 8:14:21

I finally initiated vortioxetine today at 5 mg/day.

I've noticed a definite, but still modest, effect. I feel a slight improvement in mood, cognition, and attention. I am less certain about a stimulant-like effect with regard to amelioration of apathy.

I've tried to find research on the effects of vortioxetine on dopamine. I did not find anything intriguing, only comments in passing about an increase in the release of dopamine and several other neurotransmitters (at least serotonin, noradrenaline, acetylcholine, and histamine).

I found this interesting citation:
... Antidepressants had a positive effect on psychomotor speed ...
Of note, after removal of vortioxetine from the analysis, statistical
significance was lost for psychomotor speed.

All in all the trial is off to a good start.




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