Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Guidance on blood tests results for bupropion?

Posted by Gabriel14 on March 10, 2021, at 23:27:35

In reply to Re: Guidance on blood tests results for bupropion?, posted by linkadge on March 9, 2021, at 16:50:53

> Interesting.
> There is only one antidepressant I know of (nortriptyline) for which a therapeutic blood level has been established.
> The fact that you have lower bupropion, but higher hydroxybupropion indicates to me that you may be a faster metabolizer of bupropion. However, from what I understand, a significant degree of wellbutrin's antidepressant effect is from the metabolites. So a lower level of bupropion may not be detrimental. Personally, I would go based on therapeutic responses. Do you feel your depression is being adequately treated? If not, have you considered a higher dose? If not, have you tried other agents (i.e. SSRIs) which may augment it? For example, even a low dose of escitalopram may augment it. Zoloft may be an option too, however it can increase blood levels of bupropion (to keep in mind).
> Linkadge

Thanks, Linkadge. That's an interesting point on the lower bupropion levels perhaps having to do with it being metabolized fast.

However, my hydroxybupropion levels are also below the reference range - not as dramatically so as the bupropion, but below nevertheless. So it seems like there's a potential issue here no matter how you cut it.

As far as my response, I've been on Wellbutrin for over a decade, and overall the experience has been positive, but I do feel like the effectiveness varies from batch to batch, even with the brand name.

That's actually why I had this test done; I felt like my most recent batch of Wellbutrin has been a dud, and it convinced me that maybe it was a good idea, going forward, to start tracking its levels in my blood shortly after I start each new batch.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Gabriel14 thread:1114047