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Re: Guidance on blood tests results for bupropion?

Posted by linkadge on March 9, 2021, at 16:50:53

In reply to Guidance on blood tests results for bupropion?, posted by Gabriel14 on March 9, 2021, at 15:47:05


There is only one antidepressant I know of (nortriptyline) for which a therapeutic blood level has been established.

The fact that you have lower bupropion, but higher hydroxybupropion indicates to me that you may be a faster metabolizer of bupropion. However, from what I understand, a significant degree of wellbutrin's antidepressant effect is from the metabolites. So a lower level of bupropion may not be detrimental. Personally, I would go based on therapeutic responses. Do you feel your depression is being adequately treated? If not, have you considered a higher dose? If not, have you tried other agents (i.e. SSRIs) which may augment it? For example, even a low dose of escitalopram may augment it. Zoloft may be an option too, however it can increase blood levels of bupropion (to keep in mind).





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