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Re: Medicines/Supplement that might help 4 coronavirus

Posted by PeterMartin on March 5, 2020, at 1:23:18

In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 5, 2020, at 1:14:28

n/m this seems to suggest palmitoylethanolamide supplementation could pose some risk for bipolars of which I am one.

Don't need a manic episode right now so unless I"m reading that wrong this is one sup I'll skip. It's interesting that pot has almost always been in my system when I've gone manic (many times from '99 to '09). Ever since I stopped in 2009 I've only had had one break in 2015 when I had to discontinue Marplan and started Belviq (now off the market).

Familial abnormalities of endocannabinoid signaling in schizophrenia
Objectives: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states.

Methods: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits.

Results: Twin pairs discordant for schizophrenia or bipolar disorder had significantly higher levels of anandamide and palmitoylethanolamide compared to healthy twins (both P&#8201;<&#8201;0.002). Non-affected twins discordant for schizophrenia, who developed a psychotic disorder within 5 years follow-up showed lower anandamide (P&#8201;=&#8201;0.042) and 2-arachidonoyl-sn-glycerol levels (P&#8201;=&#8201;0.049) than twins who remained healthy.

Conclusions: We suggest that the protective upregulation of endocannabinoid signalling reflects either a hereditary trait or mirrors a modulating response to genetically influenced cerebral function involving, e.g., other neurotransmitters or energy metabolism.




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