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Re: whats a drug that blocks DAT(dopamind transporter)

Posted by farshad on February 6, 2018, at 15:13:53

In reply to Re: whats a drug that blocks DAT(dopamind transporter) farshad, posted by SLS on February 6, 2018, at 15:03:25

> I hope you didn't depend on a cherry-picked post located on a public forum. Bupropion is also quoted as occupying only 14% of DAT in the original article to be found here:
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514842/
>
> Even the 14% is not a reliable value as is described in the article.
>
> Modafinil is often cited as being a DAT inhibitor.
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696807/
>
> Again, DAT inhibition is not sufficient for a compound to produce an antidepressant effect.
>
> Where did you find the numbers regarding DAT occupancy as it relates to antidepressant and euphoric effects?
>
> What drugs are you considering tying given the information you have compiled?
>
>
> - Scott

well the creators of wellbutrin said its at 27% -

https://drugs-forum.com/threads/bupropion-doesnt-actually-increase-dopamine-new-info.263168/

Wellbutrin inhibits at 27% , sertraline is a stronger inhibitor of DAT than wellbutrin so it has to be more than 27% so the 2 together 50% DAT inhibition = anti depressant effect

The DAT occupancy was just based of SERT , Since serotonin transporter inhibition needs to be over 50% to produce an anti depressant effect, Thus I assumed same for The Dopamine transporter but I could be wrong


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