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Re: whats a drug that blocks DAT(dopamind transporter) farshad

Posted by SLS on February 6, 2018, at 15:03:25

In reply to Re: whats a drug that blocks DAT(dopamind transporter), posted by farshad on February 6, 2018, at 10:42:38

I hope you didn't depend on a cherry-picked post located on a public forum. Bupropion is also quoted as occupying only 14% of DAT in the original article to be found here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514842/

Even the 14% is not a reliable value as is described in the article.

Modafinil is often cited as being a DAT inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696807/

Again, DAT inhibition is not sufficient for a compound to produce an antidepressant effect.

Where did you find the numbers regarding DAT occupancy as it relates to antidepressant and euphoric effects?

What drugs are you considering tying given the information you have compiled?


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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