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Re: why did zyprexa work but not seroquel for anxiety Farshad

Posted by SLS on January 25, 2018, at 12:01:47

In reply to why did zyprexa work but not seroquel for anxiety, posted by Farshad on January 25, 2018, at 4:53:39

> I have social anxiety and the only med that has ever worked is zyprexa but why ? I thought at first was becuase it blocks serotonin receptors but so does seroquel and that 1 didnt work.

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Olanzapine (Zyprexa):

"From the thienobenzodiazepine class (TBZ), Olanzapine (2-methyl-4-(4-methyl-l-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine) (Zyprexa) was used as an example to demonstrate the antagonism of this class of compounds for multiples receptors including: dopamine D1-D5, α-adrenoreceptor, histamine H1, muscarinic M1-M5 and 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3 and 5-HT6 receptors."

https://www.ncbi.nlm.nih.gov/pubmed/25694077

--------------------------------

Binding affinities:

https://pdsp.unc.edu/databases/pdsp.php?receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testLigandDD=&testFreeRadio=testFreeRadio&testLigand=olanzapine&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1096716
URL: http://www.dr-bob.org/babble/20161215/msgs/1096722.html