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Re: Ketamine infusions for Depression SLS

Posted by Edward807 on December 3, 2016, at 16:03:55

In reply to Re: Ketamine infusions for Depression Edward807, posted by SLS on December 3, 2016, at 6:55:57

> Hi, Edward.
> Perhaps there advantages to using sublingual lozenges. Would you know?
> I think intranasal administration allows for ketamine to bypass the blood-brain barrier and reach its target sites more directly. Sublingual doesn't do this.
> If you can get enough ketamine in the brain to produce a mild dissociative state, then it is probsbly getting to where it needs to go.

Hi Scott,

I agree, it would seem that intranasal administration would be more effective. Perhaps the lozenges they are using contain a larger dose of ketamine or the rate of absorption makes a difference.

Janssen Pharmaceuticals has several intranasal esketamine trials going on that I'm looking into.





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