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Re: Adding Parnate and prazosin. sigismund

Posted by SLS on March 3, 2012, at 21:26:21

In reply to Re: Adding Parnate and prazosin. SLS, posted by sigismund on March 3, 2012, at 17:18:59

> >Yay for polypharmacy!
>
> Maybe.
>
> Before the prazosin polypharmacy was not so good, was it?

Is that question meant to relate to my condition in particular of to those of everyone else?

Polypharmacy has certainly served me better than all of the monotherapeutic treatments I have tried over the last 30 years.

I recently tried to discontinue Abilify. I relapsed after two weeks. Fortunately, I was able to recapture a response within two days.

Is there something inherently unscientific about using more than one drug at a time to treat an illness? I really don't understand on what basis polypharmacy should be discouraged. CV diseases often require 3 drugs to manage hemodynamics and cardiac conduction. Is there something about the fundamental nature of mental illness that dictates that a single pharmacological action always be sufficient to treat it? Unfortunately, it would seem that the converse is true. Most of the drugs we currently use possess more than one pharmacological property. Perhaps a single biological target will one day emerge as the only site necessary to modulate. But that is not today.

Ed_Uk2010 mentioned that prazosin might work in conjunction with a norandrenergic drug to treat depression. I don't know what condition or symptoms you are trying to treat, though. I have always been unclear on this. It won't hurt to try prazosin as monotherapy, but I wouldn't forever cast the drug aside if it doesn't help treat MDD or BD.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1005781
URL: http://www.dr-bob.org/babble/20120302/msgs/1012329.html