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Re: Adding Parnate and prazosin.

Posted by SLS on February 23, 2012, at 6:37:39

In reply to Re: Adding Parnate and prazosin. ed_uk2010, posted by sigismund on February 22, 2012, at 16:36:16

> Eddy, does Scott's response to prazosin surprise you?

I don't know if Ed is surprised, but I certainly am. However, there is a reason for everything - we just don't know it yet. I can't be unique. I'm sure others will respond to prazosin as well. I haven't recommended it to anyone yet, though. I am hoping that some people will try prazosin on their own initiative based upon my reporting.

It may be that the antagonism by prazosin of NE alpha-1b receptors reduces neuronal activity in circumscribed areas known to be hyperactive in depression, including subgenual cingulate and nucleus accumbens. These areas just so happen to have populations of these receptors.

Interestingly, prazosin antagonism of NE alpha-1b receptors reduces activity in areas known to be stimulated by amphetamine and cocaine. I bet prazosin can aid in treating addiction to these to stimulants. It is hypothesized that global reduction in 1b receptor activity is partly responsible for producing depression. However, the interactions between circuits is complex. I don't think prazosin will be a successful treatment for everyone. I am interested in characterizing the subtypes or symptomatological profile of people who will respond to prazosin.

For now, I would like to propose the idea that prazosin, in combination with antidepressant medication, will help resolve depressions that evolve due to developmental PTSD wherein the PTSD is occult, operating in the background and driving the depression. This would indicate that people who suffered physical abuse, emotional abuse, or neglect early in life would have a good chance to respond to prazosin.

I am really not terribly interested in performing intense research regarding prazosin and its neurobiology right now. I am too involved in enjoying its results.


- Scott



Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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