Psycho-Babble Medication | about biological treatments | Framed
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Re: Linkadge, I could use your help.

Posted by bleauberry on February 22, 2012, at 4:24:32

In reply to Re: Linkadge, I could use your help., posted by linkadge on February 20, 2012, at 19:17:35

Very interesting. Most of the things I talk about often....inflammation, infection, toxins...have a common by-product....elevated glutamate.

> Hmm. Some of the things that come to mind are:
> Over-activation in parietal / occipital regions (a trait marker in familial depression)? Glutmate levels appear to be elevated even in non-depressed offspring.
> Low gaba (and hence elevated glutamate?) in the occipital lobes has also been found in other studies of depression. Gaba levels are elevated by successful SSRI treatment.
> Glutamate has been shown to be elevated in the prefrontal cortex of depression and bipolar disorder. In stress induced models of depression, the prefrontal cortex appears particularly sensitive.
> The only other regions that come to mind are limbic regions and as you mention Broadmann's area 25. The area 25 serves as kind of a gateway of the feedback loop between the prefrontal regions and limbic regions. I think some studies have linked depression to reduced volume in the cingulate area. The reduced volume might cause inefficient filtering of incoming stimuli and hence over activation of both regions.
> Linkadge




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