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Re: Feeling better during Nardil taper-off?

Posted by bleauberry on December 1, 2011, at 14:30:07

In reply to Feeling better during Nardil taper-off?, posted by pedr on November 30, 2011, at 9:05:40

I've experienced that rebound improvement on various meds, zoloft being the most notable for me. Saw it happen to a friend also. Various posters have commented on experiencing this phenomenon.

I believe there is a unique custom dose for each person, where either too much or too little is not nearly as good as just right. Of course we can only find out what just right is with time and experimentation. Maybe you accidentally discovered your new just right dose window is around 15mg? Maybe some stuff has been fixed or reset during your time on nardil and now not as much is needed for maintenance? Dunno, just thinking out loud.

My gut instinct though is it is a temporary rebound but I would love to be wrong.

I think what happens is this: (thinking out loud) There is a flood of neurotransmitters at the synapse and everything is adapted to that...the firing mechanisms have slowed down because the feedback mechanisms are telling them there is already more than enough....but then when the med is reduced or stopped the flood of neuros gets quite thin....the feedback mechanisms pick up on that and send signals to speed up firing....that is when we all of a sudden feel great, with all the new firing going on....but then the feedback mechanisms sense things are back in balance now and so the firing is slowed down....and we feel worse again. Just a crazy theory. In other words, the time of feeling good was a particular stage of the body as it begins searching for a new homeostasis. to match its new environment.

If it were me I would definitely stay at 15mg for a while and see what happens. Then I would decide whether to stay, go back up higher again, or wean off more.




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