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Re: Best Bipolar II with depression cocktail? ajax1

Posted by SLS on July 13, 2009, at 21:21:57

In reply to Re: Best Bipolar II with depression cocktail?, posted by ajax1 on July 13, 2009, at 20:09:44

> Scott-concerning your friend who takes Wellbutrin and Seroquel, does he take Seroquel during the day as well as night and perhaps you might know the mgs of each. That combination sounds pretty good to me.
> thanks
> ajax

She takes:

Wellbutrin 300mg
Seroquel 800mg
Neurontin 900mg
Abilify 30mg

Her illness is bipolar with severe depression and psychotic mixed-states. I don't think she would need so much Seroquel if she weren't taking the Abilify. I think it possible that Abilify might antagonize the actions of other antipsychotics.

At one point, she was placed on Risperdal 3mg. That helped clear up the psychotic mixed-state, but left her depressed. I swear it only took the addition of 100mg of Seroquel to lift her out of depression completely. Take away the Risperdal, and she needed the 800mg of Seroquel to control the psychotic mixed-state.

What I glean from her case is that Seroquel can provide an antidepressant effect when combined with Wellbutrin and Neurontin. I don't usually consider Neurontin to be particularly effective as a mood stabilizer, but we can't at this point eliminate it from her equation.

Studies with Seroquel as an antidepressant have used dosages of 150-300mg.

- Scott




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