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Re: Mirapex dosage as add-on antidepressant? Phillipa

Posted by SLS on September 2, 2008, at 5:52:58

In reply to Re: Mirapex dosage as add-on antidepressant? SLS, posted by Phillipa on September 1, 2008, at 23:41:09

> Scott sorry hyjacking for a quick question why is geodon at 40mg better with anxiety than 20mg I don't get that. Phillipa

Geodon (ziprasidone) potently antagonizes (blocks) 5-HT2c receptors at low dosages that do not promote the binding to dopamine (DA) receptors. Without DA antagonism, someone can experience activation, agitation and anxiety. This is what occurs at 20mg. At 40mg, Geodon now blocks enough DA receptors to conteract 5-HTc receptors and promote calmness.


- Scott

 

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URL: http://www.dr-bob.org/babble/20080822/msgs/849846.html