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Re: Reserpine for depression

Posted by SLS on September 10, 2005, at 9:36:10

In reply to Re: Reserpine for depression, posted by SLS on September 9, 2005, at 10:59:21

> > In conjunction with an MAOI?

> I don't know how safe it would be. The initial flood of catecholamines might produce a hypertensive event.

I just read that reserpine does not cause catecholamines to be released into the synapse. It prevents catecholamine uptake into the vesicles by inactivating the vesicular pump. This results in catecholamine depletion as the unprotected catecholamine in the cytosol is subject to deamination by MAO.

- Scott




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