Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Inositol / Lithium

Posted by Questionmark on March 14, 2004, at 1:53:31

In reply to Re: Inositol / Lithium, posted by linkadge on March 7, 2004, at 10:54:16

> I had the EXACT same question.
> Basically I was on lithium, and wanted to know if when I supplemented with inositol weather this would reverse the BDNF enhancing effects of the drug.
> I have heard that inositol while does not directly enhance serotogenic function it resensitizes the serotonin receptors as well as acting as a second messenger to the serotonin system.
> Lithium however blocks the presynaptic autoreceptor. When this receptor is activated serotogentic firing is attenuated. Thus blockade of the receptor keeps neurons firing. As well lithium facilitates uptake of tryptohpan into the brain. I found the effect of lithium much augmented when consumed with a high tryptophan meal.
> Linkadge

Thanks everyone for your helpful responses. That's interesting what Metalblade said about lithium inhibiting the absorption of calcium in the brain and thereby helping to prevent neuronal death. That would make sense i think.
Linkadge, i think that all that you said about inositol is correct. And i totally forgot that lithium is supposedly a serotonin autoreceptor (5-HT1A i believe?) antagonist. So thank you. All of that actually helped answer my question a great deal. i'm still curious why lithium decreases inositol (or inositol-containing compounds) concentration in brain cells, though. Hm. i wonder if it's possible-- going by this information-- that increased intracellular inositol concentrations are positively correlated with enhanced Ca2+ absorption into neurons. Shoot. This would make sense, wouldn't it? An increase in neurotransmission automatically utilizes more Ca2+ in those respective neurons, doesn't it? Or no? If so, then increased inositol ~=~ greater neurotransmission (in some brain areas, such as those that use serotonin at least) which ~=~ increased neuro-cytotoxicity which ~=~ increase in neuronal/dentritic death/decay. Is this possibly accurate at all, or am i entirely off base? Now i'm really curious. Inositol is a wonderful substance if it's not potentially neurotoxic at all.
P.S.-- very interesting anecdote, alathea.




Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Questionmark thread:321523