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Re: Reboxetine (not approved in U.S.? FDA blows!)

Posted by Caleb462 on June 19, 2003, at 12:04:23

In reply to Re: Reboxetine (not approved in U.S.? FDA blows!) McPac, posted by Barbara Cat on June 19, 2003, at 11:58:25

> > "Already psychiatrists are buzzing with news of reboxetine, which totally ignores serotonin and goes after norepinephrine"
> >
> > >>>>>>>Isn't increased norepin. bad for ocd though?
> Exactly my thought, although everything I've read on it looks intrigueing. I thought NE made anxiety worse, triggered hypomania, was involved in the fight/flight cortisol response, was excitatory. Something else is going on with these meds besides the obvious neurotransmitter model.

Well, yes.. that is the ACUTE reaction to increased norepinephrine. And in the first few weeks of treatment with Reboxetine, one might experienced increased anxiety. However... the adrenergic system downregulates in response to this increased NE... and after a few weeks, overall stress is DECREASED. That is the theory, anyway.




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