Psycho-Babble Medication | about biological treatments | Framed
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Posted by Shawn. T. on November 12, 2002, at 1:54:24

In reply to Re: Buspar - increases or decreases serotonin? ZeeZee, posted by Ritch on November 11, 2002, at 20:47:45

Buspirone (Buspar) is actually a partial agonist at 5-HT1A receptors. It also acts as an antagonist at dopamine D2 receptors. Buspirone decreases rather than increases serotonin availability in the brain. The substance P inhibitors decrease serotonin availability as well. Taking 5-HTP will increase anxiety symptoms; the manufacturer of Buspar is correct in stating that excess serotonin can cause anxiety. Most pdoc's don't understand serotonin very well at all; you apparently knew more than your pdoc with regards to this issue. The serotonin hypothesis of depression is bunk; see the second link.





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