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Re: Nice table Scott petters

Posted by SLS on May 9, 2002, at 18:46:04

In reply to Re: Nice table Scott, posted by petters on May 9, 2002, at 8:57:51

Hi Petters.

> Very glad to hear from you again. I have been thinking about you, and your condition. Very sorry for the bad side effect from Litium. Im sure that you know , that giving it a fair chans taks up to severel month. Do you think there is a chans that the side effect possible wean off after some month?

Maybe. However, lithium has consistently worsened my depression at dosages of 600mg and higher. This worsening does not subside after 9 months. I really didn't think lithium would affect me negatively at dosages as low as 100mg. I wanted to take 300mg lithium indefinitely because of the recent reports describing it as having neuroprotective and neurotrophic properties. I'm pretty pissed.

> What about Topamax + Lamictal ( I know you use Lamictal, 300 mg, if my memory is not wrong ) There seems to be many positive result from this combo in treating affective syndrom.

Really? My doctor mentioned Topomax a while ago. I am afraid of the cognitive disturbances it can produce.

I am becoming more interested in trying the anticonvulsant Gabitril (tiagabine). Gabitril increases GABAergic neurotransmission by inhibiting the reuptake of GABA. Some people have described Gabitril as being activating. However, others have reacted very badly to it, suffering severe cognitive disturbances. For me, the following drugs have produced transient antidepressant effects:

1. Nardil (phenelzine): GABA increase
- GABA aminotransferase inhibition (reduces GABA elimination)

2. Depakote (valproate): GABA increase
- GABA transaminase inhibition (reduces GABA elimination)
- SSAD dehydrogenase inhibition (increases GABA synthesis by reducing end-product inhibition)

3. Neurontin (gabapentin): GABA increase
- increased synthesis?

Is Gabitril available in Sweden?

> I did follow your advise to raise Lamictal from 100 mg to 200 mg, and it was really positive. More energi, and more stable mood. I also raised my Effexor dosage from 150 mg to 300 mg. 300 mg seems to be an optimal dose for me;

I am very glad to hear that. Effexor 300mg seems to be the optimal dosage for most people with TRD.

> I have tried to reduced the dosage to 150 mg severel times but the depression symptom occured. So I must say Im quite satisfied with my states, except partial sexual dysfunktion. Remeron was the best in this respect in combo with Effexor. But Remeron gave me side effect that I couldnt tolerated.

Has anyone else described an increased number of infections with Remeron?

> So my combo today:
> Lamictal 200 mg
> Effexor 300 mg
> Litium (0.6 mmol/)
> Nefadar 400 mg

> I hesitate to believe that this meds combo will hold, and be sufficient in the future, because I and I know you have experienced so many cruel games with this dam... poop out

Cruel indeed. However, I think you will have good luck with this combination. It seems to me that very few people experience poop-out with Effexor or Lamictal once optimal dosages are established.

> Anyway I will think about you and your trial on SA-Me, and pray for your. You have suffer more than enough.

Thanks. I'll be praying for you too.


Take care.





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