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Re: Hey folks: Look what I found re Depakote/GABA!! Janelle

Posted by SLS on May 8, 2002, at 17:08:07

In reply to Hey folks: Look what I found re Depakote/GABA!!, posted by Janelle on May 7, 2002, at 17:44:12

Hi Janelle.

> Based on this, somehow (not sure just how) Depakote does something to enhance the presence of GABA in the brain!

Depakote (valproate) increases the amount of GABA available by inhibiting an enzyme known as GABA transaminase. This mechanism is analogous to how MAO-inhibitors work to increase the levels of the monoamines (DA, NE, 5-HT). Two other drugs I know of inhibit GABA transaminase: the MAOI Nardil (phenelzine) and the anticonvulsant Sabril (vigabatrin).

Depakote also acts to stabilize nerve cell membranes by slowing-down the movement of ions (electrically charged molecules) through sodium channels.

- Scott




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