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Re: Here's something right on Klono vs. Depa and GABA!

Posted by djmmm on May 7, 2002, at 18:42:05

In reply to Here's something right on Klono vs. Depa and GABA!, posted by Janelle on May 7, 2002, at 17:50:40

Most anticonvulsants manipulate both GABA and sertonin...depakote increases *and* decreases monoamine levels in various specific parts of the brain, also, levels of tyrosine are increased.

The increase in Dopamine is mediated by the activation of 5-ht1a receptors, decreased levels are connected to the GABA-A receptors.

Klonopin mechanism of action (from cp-online):
"Benzodiazepines act at the level of the limbic, thalamic, and hypothalamic regions of the CNS, and can produce any level of CNS depression required including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and coma. The action of these drugs is mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Central benzodiazepine receptors interact allosterically with GABA receptors, potentiating the effects of GABA and thereby increasing the inhibition of the ascending reticular activating system. Benzodiazepines block the cortical and limbic arousal that occurs following stimulation of the reticular pathways."




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