Psycho-Babble Medication | about biological treatments | Framed
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Here's something right on Klono vs. Depa and GABA!

Posted by Janelle on May 7, 2002, at 17:50:40

In reply to What about Klonopin, Depakote and GABA..., posted by Janelle on May 6, 2002, at 4:46:05

Check this out - it actually compares benzos like Klonopin directly to Depakote in their action on GABA! I think I've answered my question! (can you tell I'm just a wee bit excited?!)

"VPA affects the action of GABA (gamma amino butyric acid), similar to agents such as phenobarbital and benzodiazepines. While these sedative hypnotics appear to enhance the postsynaptic action of GABA, VPA appears to increase the amount of GABA available to the CNS. Valproate has been shown (in vitro) to increase GABA levels by increasing the activity of glutamic acid decarboxylase and inhibition of GABA transaminase."




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