Psycho-Babble Medication | about biological treatments | Framed
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Hey folks: Look what I found re Depakote/GABA!!

Posted by Janelle on May 7, 2002, at 17:44:12

In reply to What about Klonopin, Depakote and GABA..., posted by Janelle on May 6, 2002, at 4:46:05

I did a quick search and found the following about Depakote and Gaba:

"Although the mechanism of action is not established, its [Depakote's) activity may be related to increased brain levels of gamma aminobutyric acid (GABA). This may also account for its prolactin lowering effects.

Depakote (valproic acid) may also inhibit an enzyme responsible for the catabolism of GABA, potentiate postsynaptic GABA responses, affect the potassium channel or have a direct membrane stabilizing effect."

Based on this, somehow (not sure just how) Depakote does something to enhance the presence of GABA in the brain!




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