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Thanks, Fachad, U're great ... wee bit more: fachad

Posted by Janelle on May 6, 2002, at 22:58:29

In reply to Re: What about Klonopin, Depakote and GABA... Janelle, posted by fachad on May 6, 2002, at 21:59:46

Okay, you said that "Klonopin directly activates GABA receptors. It is a real benzodiazapine and is a direct agonist at the benzodiazapine/GABA receptor."

What does this mean precisely - by "activating" the GABA receptors does it mean that the Klonopin gets the GABA receptors to release more GABA? (then again, I thought that receptors don't do any releasing of chemicals!)

By being a direct agonist at the benzo/GABA receptor I know (thanks to you!) about the key and lock analogy, so the Klonopin would be the key that fits into the receptor (lock) -- so my question remains - what does the Klonopin actually *do* at the GABA receptor to activate GABA?

I guess I need a brief explanation of the "direct agonist activity" that Klonopin has on GABA!

And you'll be glad to know that all I really wanted to know about Depakote and GABA you answered when you wrote that Depokate somehow (?) "enhances" GABA activity, but it is not thru a direct agonist activity like Klonopin."

I just needed to know that Depakote apparently increases/enhances GABA activity.

So, now I'm theorizing that if Klonopin activates GABA and Depakote does too, I may have had GABA overload from being on both of those meds, or it could be that like others mentioned in my thread, the Depakote unto itself was what plunged me into that horrible depression.

Thanks for answering my follow-up question re Klonopin's action with GABA!




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