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Re: Amisulpride + SSRI - WARNING

Posted by on April 21, 2002, at 16:14:56

In reply to Re: Amisulpride + SSRI - Dangerous or not??, posted by jonh kimble on April 18, 2002, at 23:47:11

Hi Jon

I posted on this for first time above on this board - with paxil - *big mistake* .

I have recently completed 3.5 weeks amisulpride low dose for social anxiety (but mostly dysthymia).

If you did try amisulpride you'd be MUCH safer dropping paxil and adding eldepryl first. As is you are likely very high risk for dystonic reactions, and possible permanent reactions.

Unfortunately this effective medication (very much so in my case) - is also most likely to induce even at the low doses used, movement reactions (orofacial especially) in those most likely to benefit.

I strongly discourage it. If you do try anything, low olanzapine is likely much safer, but still I would tend to discourage it - much as "Old School" has posted - those with affective disorders probably have compromised dopamine systems and are MOST susceptible to these TD like reactions (can be permanent).

Be aware also that many "safety studies" are done in mania or skitzophrenia with these drugs - patients who can tolerate MASSIVE doses of these drugs for years with little or no TD or dystonic reactions - but we are the OPPOSITE, we (SP, bipolar low, affective disorder, etc) have LOW dopamine most likely (especially where shyness, low energy, low self esteem, rejection sensitivity, etc.) exist.

Your Paxil is already lowering dopamine (hence the sexual side effects). You are likely now much more *primed* for dystonic or TD reactions.





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