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Re: Remeron.... ben

Posted by Elizabeth on April 7, 2002, at 18:45:34

In reply to Re: Remeron.... Elizabeth, posted by ben on April 6, 2002, at 9:41:50

> > It is true that a lot of people (not everyone) find that the sedation decreases as they increase the dose, so it's not just theoretical. That doesn't mean that everyone will experience this. Also, 30 mg is a middle-range dose of Remeron, and it's quite possible that someone who finds 30 to be oversedating will be less sedated on 45 (for example).
> Yes, but only try and error will show this. We know a lot about drugs in vitro (or of rats -> in vivo) but very less in vivo !

I'm not talking about lab experiments, in rats or in isolated brain tissue; I'm talking about the observed effects of dose increases in live human beings. Again, that doesn't mean that everyone will experience this! But it's a far cry from being "just theoretical."

> Wow, thats pretty much - do you take such doses ? I think this would knock me out ? Okay, try and error !

I take 1200 mg/day (600 AM and 600 PM). It doesn't "knock me out." In fact, I don't notice any side effects; no sedation, dizziness, etc. It's a less potent anticonvulsant than Tegretol (that is, it requires higher doses to achieve the same effect), but it has fewer side effects, not more. It might seem reasonable that less potent drugs would be "dirtier" than more potent ones, but as it turns out, this isn't necessarily true.

> > I'm not sure what you mean by "mood stabilizer for unipolars." Can you say more about this?
> Carbamazepine, Valproate, Lamotrigine....are
> used as an adjunct in unipolar depression for
> diminishing recurrence of episodes and as an augmentation strategy.

Oh, that. There's nothing specific about Trileptal, but it is being used in bipolar disorders. My guess is that it's probably about as effective as Tegretol for relapse prevention, either way.





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