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Parnate questions (Elizabeth?)

Posted by may_b on August 9, 2001, at 9:53:15

In reply to Re: MAOI Diet Parnate-users Elizabeth, posted by may_b on August 8, 2001, at 9:22:50

> Hi Elizabeth
> > How high was your blood pressure?
> I was way too sick to ask for this information -- it was nearly impossible to talk (too weak)-- it took immense concentration. Later the doctor involved said the blood pressure was not high enough to use nifedipine (my brother was with me and reported this to me the next day). I was alternately vomitting and agitated or too weak to speak or move.
> > Parnate does potentiate the pressor response to tyramine more than Nardil does, and occasionally someone will experience significant rises in BP on Parnate alone (i.e., without any food interaction). My experience has been that this is best avoided by splitting the dose (taking no more than 10 mg in a single dose).
> I had taken 10 mg twice, one at 8 am and one at 3 pm for two days when this happened.
> > I can also easily see how adding stimulant-like drugs (such as thyroid hormones) could increase the risk of hypertension.
> I had guessed Cytomel would expand blood vessels rather than constrict?
> Sorry to go back to your emerg experience, but were the interventions similar?
> Tho I went back to the dose of 10 mg of Parnate only once a day at 8 am, and stopped the Cytomel, I have had a variable but continuous low grade headache since the HC--worse if I lean over. Much as I think Parnate is already helping me with depression, I feel extremely nervous about triggering another episode. The headache is worse after each meal, even though I am adhering to a very restrictive MAOI diet.
> When you were on Parnate, did you carry an emergency supply of nifedipine or nitrosprusside?
> [I know you were able to tolerate a more reasonable diet. I thought I had saved a copy of your posting on this subject but cannot find it in my Harddrive.]
> Although I have not had migraines too often in the last year, I have a history of them since childhood (am now 48). So I am wondering if this makes me a poor Parnate candidate.
> I appreciate any comments you'd care to make; thanks as always for your thoughts.
> [I am following your desiprimine trial with interest. All the best wishes for success,]
> may_b




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