![[dr. bob]](/oculus.jpg)
|
Dr. Bob's |
From: "Jonathan Silver" <SILVERJ@cpmail-nz.cis.columbia.edu>
Date: Thu, 28 Mar 1996 08:34:19 EST
Subject: Tetrabenazine for tardive akathisia
In speaking to the neurologists at Columbia's Movement Disorder Center, it appears that tardive akathisia is pretty resistant to treatment. You can try propoxephene and propranolol, but they don't often work. You can also try tetrabenazine (related to reserpine), but may only be available at certain centers or from Europe -- it's made by Roche and is only available by compassionate plea. You can call Robert Burke, M.D., at Columbia for more info.
Date: Fri, 25 Apr 1997 10:29:39 -0400
From: Jacqueline Aron <jaron@pipeline.com>
Subject: Tetrabenazine for tardive dyskinesia
At 09:41 AM 4/25/97 +0600, Darwin Buschman, MD wrote:
An elderly patient is suicidal secondary to shame over her tardive dyskinesia which does not improve even with increase in neuroleptic. I recall a similar case years ago where a patient recieved tetrabenazine (TBZ) from an experimental program and did well...TBZ is available curently via a research program in Texas, I believe the investagator is Jankovic [at Baylor]. It is an approved drug in both Canada and in the UK and can be gotten there with a legal rx. It is prescribed frequently at the movement disorders clinic in Winnipeg.
Please see: Jankovic J, Orman J. Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias. Neurology. 38 (3): 391-4, 1988 Mar.
Date: Fri, 13 Jun 1997 10:30:31 +0100
From: Paul Bailey <Paul.BAILEY@forenap.asso.fr>
Subject: Tetrabenazine for Tourette's
Has anyone heard of a medication (used in Canada, I understand) for Tourette's disorder called tetrabenazine? I understand it controls tics and has a low incidence of weight gain (the bane of neuroleptics). Is there an approved method of using the medication in the United States?Tetrabenazine is also available in the UK; according to the British National Formulary it is "mainly used to control movement disorders in Huntington's chorea and related disorders. It may act by depleting nerve endings of dopamine. It has useful action in only a proportion of patients and its use may be limited by the development of depression." It's a quinolizine and sold by Roche in the UK, Denmark and Norway under the name of "Nitoman" and by Takeda in Japan under the name of "Regulin."--John Rose
Date: Fri, 13 Jun 1997 12:40:57 -0500
From: "Ron G. Goldman, M.D." <rgg1@columbia.edu>
Subject: Tetrabenazine for tardive dystonia
I understand that tetrabenazine acts as a dopamine depleter similar to reserpine and that depression is a common side effect. It was suggested to a patient of mine as a treatment for tardive dystonia.
This topic is indexed under the following subjects:
![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
dr-bob@uchicago.edu
URL: http://www.dr-bob.org/tips/split/Tetrabenazine.html
Original tips copyright 1994-97 original authors.
Web page copyright 1995-97 Robert Hsiung.