Dr. Bob's Psychopharmacology Tips

Spontaneous hypertensive reactions on tranylcypromine

From: "Steven L. Dubovsky" <Steven.Dubovsky@UCHSC.edu>
Date: Tue, 7 May 1996 11:00:47 MST
Subject: Spontaneous hypertensive reactions on tranylcypromine

There are a number of reports of spontaneous hypertensive reactions on tranylcypromine (Parnate). These probably come from interaction of amphetamine like metabolite with parent drug. When necessary to continue Parnate, they have been treated with self-adminstered regular doses of phentolamine. A calcium-channel blocker might work, but no one has tried this so far as I know.

From: "Jonathan Silver" <SILVERJ@cpmail-nz.cis.columbia.edu>
Date: Tue, 7 May 1996 20:50:21 EST
Subject: Spontaneous hypertensive reactions on tranylcypromine

I have seen high BP with MAOIs. It is unusual, but it can occur.

Date: Wed, 8 May 96 15:53:03 UT
From: "Jim Pfrommer" <jpfrommer@msn.com>
Subject: Spontaneous hypertensive reactions on tranylcypromine

I have also seen some of these apparent auto-induced hypertensive reactions with tranylcypromine and also attributed it to its stimulant-like properties. I was taught that 10 mg of tranylcypromine was the equivalent of one mg of dextroamphetamine.

I have seen this problem improve by dividing the doses.

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