Dr. Bob's Psychopharmacology Tips

Risk of tardive dyskinesia

Date: Fri, 29 Mar 1996 02:34:53 -0500
From: Ivan Goldberg <Psydoc@psycom.net>
Subject: Risk of tardive dyskinesia

There are a number of studies that indicate that people without schizophrenia who take antipsychotic medication are at a greater risk to develop TD than pholks with schizophrenia.

Among the mood disordered people who I treat, I have seen TD in people who have only been exposed to low-dose antipsychotics for a few months.

As for people with schizophrenia I think it was John Kane who came up with the estimate that the probability of someone developing TD is .04 for each year of exposure.

From: shakti@penn.com
Date: Sat, 30 Mar 1996 00:55:50 -0500
Subject: Risk of tardive dyskinesia

The first episode schizophrenia study ongoing at Hillside found that pts developing dystonia and pseudoparkinsonian side effects early on in the course of their first episode were more likely to develop persistent TD. This was presented at the International Congress of Schizophrenia Research last year. Interestingly I found that pts who have signs of EPS before any antipsychotic treatment are not any more likely to develop TD than those who do not. However they do develop pseudoparkinsonism secondary to antipsychotics more often. (Chatterjee et al, Am J Psych, Dec 1995)

Date: Fri, 5 Apr 1996 13:00:02 -0500 (EST)
From: John Chapman Urbaitis <jurbaiti@welchlink.welch.jhu.edu>
Subject: Risk of tardive dyskinesia

I recall a lecture some years ago in which pages from Kraepelin's 1907 textbook were shown with passages describing what we now call tardive dyskinesia.

Date: Sat, 6 Apr 1996 02:59:53 -0500
From: olson.8@osu.edu (Stephen C. Olson)
Subject: Risk of tardive dyskinesia

See this reference. Also, at a Society of Biological Psychiatry meeting (in NYC circa 1989) someone had "home movies" taken at a state hospital picnic in the 1920s showing psychiatric patients with orofacial movements which would be called TD now.

Owens DG, Johnstone EC, Frith CD. Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. Archives of General Psychiatry. 39 (4):452-61, 1982 Apr.

From: snagymd@MEM.po.com (Stephen Nagy, M.D.)
Date: Sun, 7 Apr 1996 16:41:44 -0400
Subject: Risk of tardive dyskinesia

Prof. Dr. Eugen Bleuler's Textbook of Psychiatry (A. A. Brill's authorized English version, New York: The MacMillan Company, 1924, 157-158), suggests that movement disorders were a part of the clinical progression of schizophrenic patients observed prior to the development of antipsychotic agents, although a careful reading of the text suggests that many disease entities could well have been considered to be schizophrenia.

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